Stemcentrx focused on discovering and developing targeted therapeutics particularly ADCs directed at cancer stem cells and resistant tumor populations. Its platform combined biomarker discovery, antibody engineering, and potent payload chemistry to create targeted agents intended to deliver cytotoxic drugs selectively to tumor cells. Stemcentrx emphasized translational research and companion diagnostics to identify responsive patient subsets. Clinical signals in small cell lung cancer and other tumor types drew investor interest and strategic collaborations.
What Is Stemcentrx and What Does It Do?
Stemcentrx, founded in 2008 by Scott Dylla, is a San Francisco–based (United States) biopharma company focused on antibody-drug conjugates and cancer stem-cell biology. It employs 51-200 people and advanced multiple ADC candidates into clinical trials, developing companion diagnostics to match patients to therapy. The company’s approach aimed to improve therapeutic index and durability of responses by delivering highly potent payloads selectively to tumor cells.
How Much Funding Has Stemcentrx Raised?
1. Series G
- Amount Raised: $250M
- Date: Aug 2015
- Lead Investors: Fidelity Investments, Founders Fund, Artis Ventures
- Motivation: Support late preclinical and early clinical development, IND filings, and translational programs.
2. Series B (earlier)
- Amount Raised: $23.5M
- Date: Mar 16, 2011
- Motivation: Advance lead programs into IND and Phase I testing.
Total Funding Raised: $500M
Latest Funding Date: Aug 2015
Key Investors
1. Fidelity Investments
- Details: Large institutional investor backing biotech and healthcare growth companies.
- Investment Focus Areas: Biopharma, healthcare services, biotech R&D.
- Notable Investments: Moderna, Illumina, Alnylam, Stemcentrx.
2. Founders Fund
- Details: Venture firm investing across deep tech and biotech.
- Investment Focus Areas: Deep science, biotech, defense, AI.
- Notable Investments: SpaceX, Palantir, Stemcentrx, Stripe.
3. Artis Ventures
- Details: Early-stage investor focused on technology and life sciences.
- Investment Focus Areas: Biotech, diagnostics, platform technologies.
- Notable Investments: Stemcentrx, MyoKardia, AgBiome.
Where Is Stemcentrx’s Headquarters?
Stemcentrx is headquartered in San Francisco, California, close to major biotech research institutions and clinical partners.
What’s Next for Stemcentrx?
Following strategic transactions, Stemcentrx’s scientific assets continue via partners or acquirers; next steps typically involve partnering programs, further clinical development, and companion diagnostic validation to match patients to ADC therapies.
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